Q-omics provides the consensus-scored CA5A profile across patient tissues and cancer cell-line models. CA5A expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, CA5A is differentially expressed in 9, with the highest sampling consensus in THCA. Additionally, CA5A RNA expression shows 11,454 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight UCS, THCA, and TGCT as cancer lineages where CA5A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CA5A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CA5A survival associations across molecular data types. CA5A RNA expression shows survival associations in the most cancer types (22), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CA5A RNA expression–survival associations across cancer types. High CA5A expression shows unfavorable associations in UCS, THCA, KIRC and CHOL, but favorable associations in LIHC and LUAD. The UCS Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .011). Together, the overview and detailed table identify UCS as the clearest survival context for CA5A RNA expression.
This table summarizes CA5A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for CA5A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CA5A shows lower tumor expression in THCA, KIRC, KICH and CHOL and higher tumor expression in HNSC and LUAD. The THCA box plot shows higher CA5A RNA expression in normal versus tumor tissue (log2 FC = −0.351, t-test p < 0.001).
This table shows molecular features associated with CA5A in patient tissues and cancer cell lines. In patient samples, CA5A shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, CA5A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in BONE and CNS.
