CA5A

Across TCGA pan-cancer cohorts, CA5A RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CA5A’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CA5A RNA is repressed in tumor relative to normal tissue. In most cancer types CA5A is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where CA5A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CA5A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.351	<.001	11	view →
KIRC	Male	II,III,IV	−0.137	<.001	9	view →
KICH	All	II,III,IV	−0.185	<.001	8	view →
HNSC	All	All	+0.013	.004	6	view →
CHOL	Male	All	−2.546	<.001	5	view →
LUAD	All	All	+0.043	<.001	5	view →
BRCA	All	II,III,IV	+0.009	.015	4	view →
STAD	Male	II,III,IV	+0.026	.006	3	view →
COAD	All	All	+0.024	.006	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CA5A–THCA

Open the THCA breakdown →