CA5A

Across TCGA pan-cancer cohorts, CA5A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CA5A data layer compared with 3 for mutation status.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher CA5A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CA5A expression acts as an unfavorable survival marker, although some lineages such as LIHC and LUAD show a favorable association.

UCS, THCA, and KIRC are the cancer types where CA5A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	III,IV	0.150	0.565	.011	64	view →
THCA	OS	Median	II,III,IV	0.692	0.896	.001	53	view →
KIRC	DFS	Median	III,IV	0.350	0.563	<.001	40	view →
CHOL	OS	Median	III,IV	0.162	0.915	.004	33	view →
LIHC	OS	Tertile	All	0.879	0.682	<.001	30	view →
LUAD	OS	Quartile	All	0.652	0.398	.009	29	view →
ACC	DFS	Quartile	III,IV	0.442	0.930	.017	21	view →
HNSC	DFS	Tertile	IV	0.421	0.255	.013	16	view →
UVM	OS	Tertile	All	0.407	0.777	.018	15	view →
TGCT	OS	Tertile	All	0.924	1.000	.042	12	view →
KICH	OS	Median	II,III,IV	0.636	0.962	.003	10	view →
STAD	DFS	Tertile	IV	0.377	0.996	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CA5A–UCS (DFS)

Open the UCS breakdown →