CA5A

Across TCGA patient cohorts, CA5A mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CA5A-associated genes across cancer lineages are JNK2, MEK1, and p62 Lck ligand. Each is linked with CA5A in more than 1 cancer types. Because this analysis shows association rather than direction, both CA5A-to-partner and partner-to-CA5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CA5A-low versus CA5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA5A→partner) and Y-score (partner→CA5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.173	+2.115	.046	.019	3	1
UCEC	MEK1 →	+0.399	+3.321	.012	.010	3	1
UCEC	p62 Lck ligand →	+0.478	+3.179	<.001	.010	3	1
UCEC	Caspase-8 →	-0.221	-3.432	.044	.005	3	1
UCEC	MSH2 →	-0.280	-3.312	.005	.010	2	1
UCEC	p27_pT198 →	+0.185	+3.169	<.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

JNK2 by CA5A expression — UCEC

Explore this box plot interactively →