Across TCGA pan-cancer cohorts, SERPINA5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SERPINA5 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SERPINA5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SERPINA5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and COAD are the cancer types where SERPINA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.960	0.661	<.001	57	view →
PDAC	OS	Quartile	III,IV	0.988	0.618	.007	15	view →
COAD	DFS	Median	III,IV	0.829	1.000	.027	12	view →
UCEC	DFS	Quartile	All	0.971	0.736	.015	6	view →
GBM	OS	Tertile	All	0.236	0.537	.015	4	view →
LSCC	DFS	Tertile	II,III,IV	0.868	1.000	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: SERPINA5 tumor-vs-normal RNA expression · all SERPINA5 data types