Across TCGA patient cohorts, SERPINA5 mutation is significantly associated with the RNA expression of many other genes, with 1,483 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA5-associated genes across cancer lineages are EXOSC8, PARP2, and TTC5. Each is linked with SERPINA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINA5-to-partner and partner-to-SERPINA5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA5→partner) and Y-score (partner→SERPINA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EXOSC8 →	+0.496	+3.807	<.001	<.001	3	3
LUAD	PARP2 →	+0.588	+2.637	<.001	.005	3	3
LUAD	TTC5 →	+0.415	+3.506	.004	.002	3	3
LUAD	NDUFB6 →	+0.519	+2.712	<.001	.003	3	3
UCEC	LGR4 →	+0.934	+2.711	.006	.003	3	3
HNSC	STSP1 →	+0.035	+4.063	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,483 associations by consensus.

Exploration

SERPINA5 survival (RNA) · tumor vs normal (RNA) · all SERPINA5 data types