Across TCGA patient cohorts, SERPINA5 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA5-associated genes across cancer lineages are 4E-BP1, Caspase-8, and p70-S6K. Each is linked with SERPINA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA5-to-partner and partner-to-SERPINA5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA5→partner) and Y-score (partner→SERPINA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1 →	+0.313	+2.820	.034	.035	3	2
SKCM	Caspase-8 →	-0.145	-1.700	.012	.040	3	2
LUAD	p70-S6K →	+0.224	+3.000	.035	.035	3	1
LUAD	YAP_pS127 →	-0.392	-3.321	.028	.010	3	1
LUAD	4E-BP1_pS65 →	+0.158	+3.321	.022	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.286	+2.183	.008	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

SERPINA5 survival (RNA) · tumor vs normal (RNA) · all SERPINA5 data types