Across TCGA pan-cancer cohorts, SERPINA5 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SERPINA5’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SERPINA5 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SERPINA5 is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

CCRCC, LUAD, and COAD are the cancer types where SERPINA5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SERPINA5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	−1.080	<.001	11	view →
LUAD	Female	III,IV	−1.463	<.001	9	view →
COAD	Female	III,IV	−0.584	<.001	9	view →
LSCC	Female	All	−1.377	<.001	8	view →
HNSC	Male	IV	−1.094	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SERPINA5 RNA expression & survival · all SERPINA5 data types