serpin family A member 4Genealiases: KAL · KLST · KST · PI-4 · PI4 · kallistatin
Q-omics provides the consensus-scored SERPINA4 profile across patient tissues and cancer cell-line models. SERPINA4 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, SERPINA4 is differentially expressed in 12, with the highest sampling consensus in KIRC. Additionally, SERPINA4 protein abundance shows 27,484 significant protein co-abundance associations, with the highest sampling consensus in PDAC. Together, these results highlight KIRC, and PDAC as cancer lineages where SERPINA4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SERPINA4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SERPINA4 survival associations across molecular data types. SERPINA4 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (3) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SERPINA4 RNA expression–survival associations across cancer types. High SERPINA4 expression shows unfavorable associations in KIRC, ACC, CHOL and LGG, but favorable associations in UCEC and LIHC. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for SERPINA4 RNA expression.
This table summarizes SERPINA4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 6. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for SERPINA4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SERPINA4 shows lower tumor expression in KIRC, KICH, KIRP and LIHC and higher tumor expression in LUAD and COAD. The KIRC box plot shows higher SERPINA4 RNA expression in normal versus tumor tissue (log2 FC = −2.369, t-test p < 0.001).
This table shows molecular features associated with SERPINA4 in patient tissues and cancer cell lines. In patient samples, SERPINA4 shows the broadest associations at the RNA and protein expression levels, with PDAC recurring as the lineage with the largest associated feature set. In cancer cell lines, SERPINA4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in BREAST and SOFT_TISSUE.
