SERPINA4

Across TCGA cell cohorts, SERPINA4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SERPINA4-associated genes across cancer lineages are ACOD1, KRTAP21-2, and OR5G3. Each is linked with SERPINA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA4-to-partner and partner-to-SERPINA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACOD1 grouped by SERPINA4-low versus SERPINA4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA4→partner) and Y-score (partner→SERPINA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ACOD1 →	+0.006	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP21-2 →	+0.136	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR5G3 →	+0.044	+4.867	<.001	.009	3	1
LUNG_SCLC	OR4S1 →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	C4orf51 →	+0.559	+4.643	<.001	.004	3	1
LUNG_NSCLC_LUAD	SLC22A8 →	+0.017	+3.628	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ACOD1 by SERPINA4 expression — BLOOD_Lymphoma

Explore this box plot interactively →