SERPINA4

Across TCGA pan-cancer cohorts, SERPINA4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SERPINA4 data layer compared with 19 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SERPINA4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SERPINA4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, COAD, and GBM are the cancer types where SERPINA4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.881	0.541	.002	44	view →
COAD	DFS	Median	II,III,IV	0.880	1.000	.020	24	view →
GBM	OS	Median	All	0.914	0.635	.001	13	view →
LSCC	OS	Median	II,III,IV	0.902	1.000	.017	6	view →
HNSC	OS	Median	All	0.956	1.000	.014	2	view →
LUAD	OS	Quartile	II,III,IV	0.318	0.866	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SERPINA4–CCRCC (DFS)

Open the CCRCC breakdown →