SERPINA4

Across TCGA patient cohorts, SERPINA4 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA4-associated genes across cancer lineages are Notch1, p62 Lck ligand, and PCNA. Each is linked with SERPINA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINA4-to-partner and partner-to-SERPINA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SERPINA4-low versus SERPINA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA4→partner) and Y-score (partner→SERPINA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.150	+2.335	.010	.018	3	3
UCEC	p62 Lck ligand →	+0.426	+2.710	.001	.003	3	2
UCEC	PCNA →	+0.224	+1.807	.012	.027	3	2
UCEC	Rb_pS807_S811 →	-0.412	-2.999	.013	.035	3	2
UCEC	Src_pY527 →	-0.513	-2.449	.003	.019	3	2
UCEC	STAT3_pY705 →	-0.431	-3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Notch1 by SERPINA4 expression — UCEC

Explore this box plot interactively →