SERPINA4

Across TCGA pan-cancer cohorts, SERPINA4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SERPINA4 data layer compared with 19 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SERPINA4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERPINA4 expression acts as an unfavorable survival marker.

ESCA, SKCM, and LUSC are the cancer types where SERPINA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.082	0.523	<.001	18	view →
SKCM	OS	Median	III,IV	0.129	0.455	.013	11	view →
LUSC	OS	Median	All	0.473	0.825	.020	10	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SERPINA4–ESCA (DFS)

Open the ESCA breakdown →