SERPINA4

Across TCGA patient cohorts, SERPINA4 mutation is significantly associated with the RNA expression of many other genes, with 1,168 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA4-associated genes across cancer lineages are LOXL1, RNU6-879P, and CACNA1C-AS1. Each is linked with SERPINA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SERPINA4-to-partner and partner-to-SERPINA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LOXL1 grouped by SERPINA4-low versus SERPINA4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA4→partner) and Y-score (partner→SERPINA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LOXL1 →	-0.745	-2.634	.001	<.001	3	4
UCEC	RNU6-879P →	+0.311	+1.944	.006	.002	3	3
UCEC	CACNA1C-AS1 →	-0.180	-2.172	.008	.002	3	3
UCEC	OR11J5P →	+0.012	+4.086	<.001	.005	3	3
UCEC	PRPF4 →	+0.479	+2.337	.001	.003	3	3
SKCM	NDUFB6 →	+0.313	+2.347	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,168 associations by consensus.

LOXL1 by SERPINA4 expression — SKCM

Explore this box plot interactively →