Q-omics provides the consensus-scored SCAMP3 profile across patient tissues and cancer cell-line models. SCAMP3 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, SCAMP3 is differentially expressed in 17, with the highest sampling consensus in HNSC. Additionally, SCAMP3 protein abundance shows 19,130 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight ACC, and HNSC as cancer lineages where SCAMP3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SCAMP3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SCAMP3 survival associations across molecular data types. SCAMP3 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (6) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SCAMP3 RNA expression–survival associations across cancer types. High SCAMP3 expression shows unfavorable associations in ACC, LIHC, KICH, UVM, KIRC and HNSC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for SCAMP3 RNA expression.
This table summarizes SCAMP3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 17, while mass-spec protein shows differences in 7. The strongest signals are observed in HNSC for RNA and PDAC for protein.
This table ranks reproducible tumor–normal expression differences for SCAMP3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SCAMP3 shows higher tumor expression in HNSC, BLCA, COAD, LIHC, STAD and LUAD. The HNSC box plot shows higher SCAMP3 RNA expression in tumor versus normal tissue (log2 FC = +0.821, t-test p < 0.001).
This table shows molecular features associated with SCAMP3 in patient tissues and cancer cell lines. In patient samples, SCAMP3 shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set. In cancer cell lines, SCAMP3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in STOMACH, while CRISPR and shRNA rows add functional-dependency signals in URINARY_TRACT and UPPER_AERODIGESTIVE_TRACT.
