SCAMP3

Across TCGA pan-cancer cohorts, SCAMP3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SCAMP3’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where SCAMP3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SCAMP3 is over-expressed in tumor.

PDAC, CCRCC, and LUAD are the cancer types where SCAMP3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCAMP3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	III,IV	+0.706	<.001	10	view →
CCRCC	Male	III,IV	+0.547	<.001	10	view →
LUAD	Female	All	+0.355	<.001	9	view →
COAD	Female	All	+0.205	<.001	9	view →
HNSC	All	All	+0.168	<.001	8	view →
LSCC	Male	All	+0.136	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SCAMP3–PDAC

Open the PDAC breakdown →