SCAMP3

Across TCGA pan-cancer cohorts, SCAMP3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SCAMP3 data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SCAMP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCAMP3 expression acts as an unfavorable survival marker, although some lineages such as DLBC and STAD show a favorable association.

ACC, LIHC, and KICH are the cancer types where SCAMP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.197	0.692	<.001	109	view →
LIHC	OS	Median	All	0.695	0.854	<.001	76	view →
KICH	OS	Quartile	All	0.538	1.000	.004	65	view →
UVM	OS	Quartile	All	0.346	0.671	.001	56	view →
KIRC	DFS	Median	III,IV	0.533	0.755	.001	43	view →
HNSC	OS	Quartile	All	0.252	0.585	<.001	40	view →
KIRP	OS	Tertile	All	0.869	0.975	<.001	38	view →
UCS	OS	Tertile	IV	0.405	0.932	.024	30	view →
CESC	DFS	Tertile	All	0.742	0.891	.001	30	view →
MESO	OS	Tertile	IV	0.213	0.748	.001	30	view →
ESCA	DFS	Median	III,IV	0.294	0.526	.003	25	view →
UCEC	OS	Median	All	0.903	0.948	.007	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SCAMP3–ACC (DFS)

Open the ACC breakdown →