SCAMP3

Across TCGA pan-cancer cohorts, SCAMP3 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SCAMP3 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SCAMP3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCAMP3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, ESCA, and UCEC are the cancer types where SCAMP3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.053	0.786	<.001	36	view →
ESCA	OS	Median	II,III,IV	0.136	0.703	<.001	24	view →
UCEC	DFS	Median	All	1.000	0.628	.020	14	view →
COAD	DFS	Median	All	0.142	0.526	.001	11	view →
LUAD	DFS	Median	II,III,IV	0.098	0.682	<.001	6	view →
SKCM	DFS	Median	III,IV	0.139	0.654	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SCAMP3–CESC (DFS)

Open the CESC breakdown →