SCAMP3

Across TCGA pan-cancer cohorts, SCAMP3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SCAMP3 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCAMP3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SCAMP3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where SCAMP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.296	1.000	.003	59	view →
LSCC	OS	Quartile	II,III,IV	0.543	0.900	.004	23	view →
LUAD	OS	Tertile	All	0.896	0.672	.021	15	view →
PDAC	OS	Median	IV	0.381	0.951	.006	12	view →
UCEC	DFS	Tertile	III,IV	1.000	0.320	.042	8	view →
GBM	DFS	Tertile	All	0.272	0.468	.036	4	view →
CCRCC	OS	Quartile	All	0.745	0.919	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SCAMP3–HNSC (OS)

Open the HNSC breakdown →