Rho associated coiled-coil containing protein kinase 1Genealiases: P160ROCK · ROCK-I
Q-omics provides the consensus-scored ROCK1 profile across patient tissues and cancer cell-line models. ROCK1 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, ROCK1 is differentially expressed in 12, with the highest sampling consensus in HNSC. Additionally, ROCK1 RNA expression shows 20,823 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, HNSC, and ACC as cancer lineages where ROCK1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ROCK1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ROCK1 survival associations across molecular data types. ROCK1 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (8) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ROCK1 RNA expression–survival associations across cancer types. High ROCK1 expression shows unfavorable associations in MESO, CESC and STAD, but favorable associations in KIRC, SKCM and HNSC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for ROCK1 RNA expression.
This table summarizes ROCK1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 7. The strongest signals are observed in HNSC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for ROCK1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ROCK1 shows lower tumor expression in BLCA, LUSC and COAD and higher tumor expression in HNSC, CHOL and LIHC. The HNSC box plot shows higher ROCK1 RNA expression in tumor versus normal tissue (log2 FC = +0.996, t-test p < 0.001).
This table shows molecular features associated with ROCK1 in patient tissues and cancer cell lines. In patient samples, ROCK1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, ROCK1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in OVARY and BLOOD_Leukemia.
