ROCK1

Across TCGA pan-cancer cohorts, ROCK1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ROCK1 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ROCK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ROCK1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where ROCK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.459	0.780	<.001	28	view →
CCRCC	OS	Quartile	III,IV	1.000	0.596	.001	20	view →
LUAD	OS	Tertile	II,III,IV	0.314	0.848	.010	5	view →
PDAC	OS	Tertile	III,IV	0.514	0.172	.045	2	view →
LSCC	OS	Quartile	All	0.923	0.741	.031	1	view →
GBM	DFS	Median	All	0.670	0.816	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ROCK1–HNSC (DFS)

Open the HNSC breakdown →