ROCK1

Across TCGA pan-cancer cohorts, ROCK1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ROCK1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ROCK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ROCK1 is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

HNSC, CHOL, and BLCA are the cancer types where ROCK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ROCK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.996	<.001	11	view →
CHOL	Male	All	+1.469	<.001	5	view →
BLCA	Male	IV	−1.330	.016	5	view →
LIHC	All	All	+0.492	<.001	5	view →
LUSC	All	All	−0.278	.003	5	view →
COAD	All	All	−0.514	.001	4	view →
UCEC	All	All	−0.949	<.001	2	view →
READ	Female	All	−0.836	.008	2	view →
KICH	Female	All	−0.737	.014	2	view →
LUAD	Female	All	−0.357	.010	2	view →
KIRP	Male	All	−0.410	.020	1	view →
KIRC	All	All	+0.239	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ROCK1–HNSC

Open the HNSC breakdown →