ROCK1

Across TCGA cell cohorts, ROCK1 mutation is significantly associated with the RNA expression of many other genes, with 1,231 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ROCK1-associated genes across cancer lineages are ADAM7, OR10K1, and AKR1A1. Each is linked with ROCK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ROCK1-to-partner and partner-to-ROCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by ROCK1-low versus ROCK1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROCK1→partner) and Y-score (partner→ROCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADAM7 →	+0.023	+4.507	<.001	.001	3	2
CNS	OR10K1 →	+0.007	+3.700	<.001	.003	3	2
LARGE_INTESTINE	AKR1A1 →	+0.548	+2.451	<.001	<.001	3	2
LARGE_INTESTINE	TEX46 →	+0.090	+2.497	.008	.001	3	2
STOMACH	MS4A13 →	+0.133	+5.285	<.001	.003	3	2
LUNG_SCLC	TAS2R7 →	+0.146	+3.736	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,231 associations by consensus.

ADAM7 by ROCK1 expression — BLOOD_Leukemia

Explore this box plot interactively →