ROCK1

Across TCGA patient cohorts, ROCK1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROCK1-associated genes across cancer lineages are S6_pS240_S244, ASNS, and Caspase-7-cleavedD198. Each is linked with ROCK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ROCK1-to-partner and partner-to-ROCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by ROCK1-low versus ROCK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROCK1→partner) and Y-score (partner→ROCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.259	+2.222	.035	.010	3	3
UCEC	ASNS →	+0.428	+3.087	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+0.725	+2.824	.028	.034	3	3
UCEC	c-Kit →	-0.147	-1.321	.037	.012	3	3
UCEC	Cyclin-E2 →	+0.142	+1.594	.005	.010	3	3
UCEC	eEF2 →	+0.228	+1.700	.035	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

S6_pS240_S244 by ROCK1 expression — UCEC

Explore this box plot interactively →