ROCK1

Across TCGA cell cohorts, ROCK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,204 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ROCK1-associated GO terms across cancer lineages are Negative regulation of bicellular tight junction assembly, Vesicle targeting, and Peptidyl-serine modification. Each is linked with ROCK1 in more than 16 cancer types. Because this analysis shows association rather than direction, both ROCK1-to-partner and partner-to-ROCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of bicellular tight junction assembly grouped by ROCK1-low versus ROCK1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ROCK1→partner) and Y-score (partner→ROCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of bicellular tight junction assembly →	+0.195	+0.940	<.001	<.001	3	17
LARGE_INTESTINE	Vesicle targeting →	+0.046	+0.770	<.001	<.001	3	15
STOMACH	Peptidyl-serine modification →	+0.067	+0.812	<.001	.005	3	14
LUNG_SCLC	Myoblast migration →	+0.224	+0.763	<.001	.001	2	15
OVARY	Microtubule polymerization →	+0.095	+1.050	<.001	<.001	3	14
LARGE_INTESTINE	Positive regulation of organelle assembly →	+0.054	+0.889	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,204 associations by consensus.

Negative regulation of bicellular tight junction assembly by ROCK1 expression — BONE

Explore this box plot interactively →