RAB38, member RAS oncogene familyGenealiases: NY-MEL-1 · rrGTPbp
Q-omics provides the consensus-scored RAB38 profile across patient tissues and cancer cell-line models. RAB38 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, RAB38 is differentially expressed in 12, with the highest sampling consensus in KIRP. Additionally, RAB38 RNA expression shows 19,248 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight SKCM, KIRP, and UVM as cancer lineages where RAB38 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RAB38 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RAB38 survival associations across molecular data types. RAB38 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (6) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RAB38 RNA expression–survival associations across cancer types. High RAB38 expression shows unfavorable associations in SKCM, ACC, SCLC, LIHC and LGG, but favorable associations in KIRC. The SKCM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for RAB38 RNA expression.
This table summarizes RAB38 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for RAB38. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RAB38 shows higher tumor expression in KIRP, KIRC, THCA, HNSC, LUSC and CHOL. The KIRP box plot shows higher RAB38 RNA expression in tumor versus normal tissue (log2 FC = +1.638, t-test p < 0.001).
This table shows molecular features associated with RAB38 in patient tissues and cancer cell lines. In patient samples, RAB38 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, RAB38 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in CNS and SKIN.
