RAB38

Across TCGA patient cohorts, RAB38 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB38-associated genes across cancer lineages are EGFR, p21, and P-Cadherin. Each is linked with RAB38 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB38-to-partner and partner-to-RAB38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by RAB38-low versus RAB38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB38→partner) and Y-score (partner→RAB38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.226	-3.143	.002	.018	3	1
UCEC	p21 →	+0.259	+2.584	.003	.011	3	1
UCEC	P-Cadherin →	-0.138	-2.311	.040	.034	3	1
UCEC	Annexin_VII →	-0.137	-2.990	.034	.036	3	1
UCEC	STAT3_pY705 →	-0.487	-2.574	<.001	.010	3	1
UCEC	Tuberin_pT1462 →	+0.281	+2.179	.009	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR by RAB38 expression — UCEC

Explore this box plot interactively →