RAB38

Across TCGA pan-cancer cohorts, RAB38 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated RAB38 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher RAB38 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RAB38 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

SKCM, ACC, and KIRC are the cancer types where RAB38 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Quartile	II,III,IV	0.754	0.927	<.001	64	view →
ACC	DFS	Median	All	0.224	0.691	<.001	63	view →
KIRC	DFS	Tertile	All	0.727	0.548	<.001	61	view →
SCLC	OS	Tertile	All	0.392	0.709	.003	60	view →
LIHC	OS	Median	All	0.606	0.764	<.001	59	view →
LGG	DFS	Median	All	0.642	0.833	<.001	54	view →
STAD	DFS	Tertile	III,IV	0.397	0.764	.001	38	view →
KIRP	OS	Median	IV	0.040	0.525	.002	30	view →
PAAD	OS	Quartile	All	0.349	0.619	.013	26	view →
READ	DFS	Median	II,III,IV	0.759	0.539	.012	26	view →
HNSC	DFS	Median	IV	0.394	0.730	<.001	21	view →
THYM	OS	Median	All	0.771	0.962	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

RAB38–SKCM (OS)

Open the SKCM breakdown →