Q-omics provides the consensus-scored PPFIBP1 profile across patient tissues and cancer cell-line models. PPFIBP1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, PPFIBP1 is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, PPFIBP1 protein abundance shows 26,302 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, HNSC, and GBM as cancer lineages where PPFIBP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PPFIBP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PPFIBP1 survival associations across molecular data types. PPFIBP1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (3) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PPFIBP1 RNA expression–survival associations across cancer types. High PPFIBP1 expression shows unfavorable associations in ACC, MESO, PAAD, BLCA and LGG, but favorable associations in KIRC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for PPFIBP1 RNA expression.
This table summarizes PPFIBP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 7. The strongest signals are observed in HNSC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for PPFIBP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PPFIBP1 shows lower tumor expression in UCEC, KICH, LUAD and THCA and higher tumor expression in HNSC and KIRP. The HNSC box plot shows higher PPFIBP1 RNA expression in tumor versus normal tissue (log2 FC = +1.558, t-test p < 0.001).
This table shows molecular features associated with PPFIBP1 in patient tissues and cancer cell lines. In patient samples, PPFIBP1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, PPFIBP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and LARGE_INTESTINE.
