PPFIBP1

Across TCGA patient cohorts, PPFIBP1 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPFIBP1-associated genes across cancer lineages are Caspase-7-cleavedD198, Notch1, and STAT5a. Each is linked with PPFIBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPFIBP1-to-partner and partner-to-PPFIBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PPFIBP1-low versus PPFIBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIBP1→partner) and Y-score (partner→PPFIBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.503	+2.019	.009	.005	3	3
UCEC	Notch1 →	+0.150	+1.598	<.001	.019	3	2
UCEC	STAT5a →	+0.339	+1.678	.008	.021	3	2
UCEC	Cyclin-B1 →	+0.698	+2.999	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.085	-1.780	.009	.024	3	1
UCEC	eEF2 →	+0.288	+2.584	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Caspase-7-cleavedD198 by PPFIBP1 expression — UCEC

Explore this box plot interactively →