PPFIBP1

Across TCGA pan-cancer cohorts, PPFIBP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPFIBP1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PPFIBP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PPFIBP1 expression acts as an unfavorable survival marker.

LSCC, PDAC, and CCRCC are the cancer types where PPFIBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.707	0.942	.008	32	view →
PDAC	DFS	Median	III,IV	0.430	0.882	.012	18	view →
CCRCC	DFS	Tertile	III,IV	0.763	1.000	.030	2	view →
LUAD	OS	Median	II,III,IV	0.784	0.998	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPFIBP1–LSCC (OS)

Open the LSCC breakdown →