PPFIBP1

Across TCGA patient cohorts, PPFIBP1 mutation is significantly associated with the RNA expression of many other genes, with 3,091 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPFIBP1-associated genes across cancer lineages are EI24P4, MIR4744, and TOMM22P6. Each is linked with PPFIBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPFIBP1-to-partner and partner-to-PPFIBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EI24P4 grouped by PPFIBP1-low versus PPFIBP1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIBP1→partner) and Y-score (partner→PPFIBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EI24P4 →	+0.032	+3.963	.001	.002	3	3
UCEC	MIR4744 →	+0.270	+1.541	.001	.005	3	3
SKCM	TOMM22P6 →	+0.042	+3.897	<.001	.009	3	3
UCEC	RNA5SP421 →	+0.426	+1.478	.001	.005	3	3
BLCA	OR8H2 →	+0.016	+4.033	.007	.009	3	2
HNSC	MRPS16P2 →	+0.059	+3.639	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,091 associations by consensus.

EI24P4 by PPFIBP1 expression — BRCA

Explore this box plot interactively →