PPFIBP1

Across TCGA cell cohorts, PPFIBP1 mutation is significantly associated with the RNA expression of many other genes, with 457 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPFIBP1-associated genes across cancer lineages are SPZ1, TFAP2D, and ITIH1. Each is linked with PPFIBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPFIBP1-to-partner and partner-to-PPFIBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPZ1 grouped by PPFIBP1-low versus PPFIBP1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIBP1→partner) and Y-score (partner→PPFIBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPZ1 →	+0.228	+4.256	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.060	+3.736	<.001	.001	3	2
BREAST	ITIH1 →	+0.064	+3.898	<.001	.005	3	2
OESOPHAGUS	CABP2 →	+0.023	+4.906	<.001	.006	3	1
LUNG_SCLC	SHCBP1L →	+0.291	+3.817	.001	.004	3	1
LUNG_SCLC	MEIKIN →	+0.255	+3.523	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 457 associations by consensus.

SPZ1 by PPFIBP1 expression — LUNG_SCLC

Explore this box plot interactively →