phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)Genealiases: EMM · GPI7 · LAS21 · MRT53 · NEDHSCA · PRO4405
Q-omics provides the consensus-scored PIGG profile across patient tissues and cancer cell-line models. PIGG expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in LGG. Among the 18 cancer types available for tumor–normal comparison, PIGG is differentially expressed in 10, with the highest sampling consensus in HNSC. Additionally, PIGG RNA expression shows 21,079 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight LGG, HNSC, and UVM as cancer lineages where PIGG shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PIGG — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PIGG survival associations across molecular data types. PIGG RNA expression shows survival associations in the most cancer types (24), followed by mutation status (7) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PIGG RNA expression–survival associations across cancer types. High PIGG expression shows unfavorable associations in LGG, LIHC and LUAD, but favorable associations in UCS, BRCA and UCEC. The LGG Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for PIGG RNA expression.
This table summarizes PIGG tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 5. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for PIGG. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PIGG shows lower tumor expression in THCA and KICH and higher tumor expression in HNSC, LIHC, STAD and CHOL. The HNSC box plot shows higher PIGG RNA expression in tumor versus normal tissue (log2 FC = +0.786, t-test p < 0.001).
This table shows molecular features associated with PIGG in patient tissues and cancer cell lines. In patient samples, PIGG shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, PIGG RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in URINARY_TRACT and BLOOD_Leukemia.
