PIGG

Across TCGA patient cohorts, PIGG mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGG-associated genes across cancer lineages are TFRC, AMPK_pT172, and Caspase-8. Each is linked with PIGG in more than 2 cancer types. Because this analysis shows association rather than direction, both PIGG-to-partner and partner-to-PIGG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by PIGG-low versus PIGG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGG→partner) and Y-score (partner→PIGG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.462	+1.925	.015	.005	3	3
SKCM	AMPK_pT172 →	+0.345	+3.000	.023	.035	3	2
SKCM	Caspase-8 →	-0.251	-3.287	<.001	.009	3	2
SKCM	C-Raf →	+0.199	+2.321	.002	.033	3	2
UCEC	JNK_pT183_Y185 →	-0.177	-1.912	.003	.005	3	2
UCEC	Shc_pY317 →	-0.177	-2.000	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

TFRC by PIGG expression — UCEC

Explore this box plot interactively →