PIGG

Across TCGA pan-cancer cohorts, PIGG RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PIGG data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher PIGG RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIGG expression acts as an unfavorable survival marker, although some lineages such as UCS and BRCA show a favorable association.

LGG, LIHC, and LUAD are the cancer types where PIGG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.657	0.819	<.001	54	view →
LIHC	DFS	Tertile	All	0.435	0.601	.001	35	view →
LUAD	DFS	Median	All	0.256	0.421	<.001	30	view →
UCS	DFS	Median	III,IV	0.458	0.126	.003	28	view →
BRCA	OS	Tertile	III,IV	0.900	0.752	.005	26	view →
UCEC	OS	Median	III,IV	0.689	0.479	.003	20	view →
MESO	DFS	Quartile	IV	0.159	0.753	.006	18	view →
HNSC	DFS	Quartile	All	0.509	0.747	.010	16	view →
STAD	OS	Median	All	0.728	0.599	.015	15	view →
CESC	DFS	Quartile	All	0.610	0.803	.005	14	view →
SKCM	DFS	Tertile	All	0.275	0.169	.006	9	view →
ACC	DFS	Tertile	IV	0.633	0.127	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PIGG–LGG (DFS)

Open the LGG breakdown →