PIGG

Across TCGA pan-cancer cohorts, PIGG mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PIGG data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PIGG mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIGG expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where PIGG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.720	0.929	.010	13	view →
HNSC	OS	Median	All	0.449	1.000	.023	10	view →
CCRCC	DFS	Median	All	0.900	0.632	.004	9	view →
LUAD	OS	Quartile	III,IV	0.879	0.340	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PIGG–PDAC (DFS)

Open the PDAC breakdown →