PIGG

Across TCGA patient cohorts, PIGG mutation is significantly associated with the RNA expression of many other genes, with 3,229 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGG-associated genes across cancer lineages are ITGB1BP1, HOMER1, and CETN3. Each is linked with PIGG in more than 3 cancer types. Because this analysis shows association rather than direction, both PIGG-to-partner and partner-to-PIGG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGB1BP1 grouped by PIGG-low versus PIGG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGG→partner) and Y-score (partner→PIGG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITGB1BP1 →	+0.302	+2.595	.005	.005	3	4
UCEC	HOMER1 →	+0.618	+2.263	<.001	<.001	3	3
UCEC	CETN3 →	+0.523	+2.518	<.001	.001	3	3
UCEC	POLR3K →	+0.455	+4.021	<.001	<.001	3	3
UCEC	SLBP →	+0.535	+4.032	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.786	+2.295	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,229 associations by consensus.

ITGB1BP1 by PIGG expression — UCEC

Explore this box plot interactively →