PIGG

Across TCGA cell cohorts, PIGG mutation is significantly associated with the RNA expression of many other genes, with 116 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIGG-associated genes across cancer lineages are OLIG3, MYH7, and EIF3E. Each is linked with PIGG in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGG-to-partner and partner-to-PIGG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OLIG3 grouped by PIGG-low versus PIGG-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGG→partner) and Y-score (partner→PIGG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OLIG3 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	MYH7 →	+0.006	+5.000	<.001	.006	3	1
LARGE_INTESTINE	EIF3E →	+0.830	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ARMC1 →	+0.407	+3.212	.008	.006	3	1
LARGE_INTESTINE	TRIM37 →	+0.719	+3.212	.001	.006	3	1
LARGE_INTESTINE	SLIRP →	+0.552	+3.212	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 116 associations by consensus.

OLIG3 by PIGG expression — PANCREAS

Explore this box plot interactively →