oxysterol binding protein like 11Genealiases: ORP-11 · ORP11 · OSBP12 · TCCCIA00292
Q-omics provides the consensus-scored OSBPL11 profile across patient tissues and cancer cell-line models. OSBPL11 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, OSBPL11 is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, OSBPL11 RNA expression shows 20,326 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, HNSC, and ACC as cancer lineages where OSBPL11 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OSBPL11 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OSBPL11 survival associations across molecular data types. OSBPL11 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (8) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OSBPL11 RNA expression–survival associations across cancer types. High OSBPL11 expression shows unfavorable associations in ACC, KICH and MESO, but favorable associations in KIRC, HNSC and LGG. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for OSBPL11 RNA expression.
This table summarizes OSBPL11 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 4. The strongest signals are observed in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for OSBPL11. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OSBPL11 shows lower tumor expression in LUAD, THCA and COAD and higher tumor expression in HNSC, KIRC and KIRP. The HNSC box plot shows higher OSBPL11 RNA expression in tumor versus normal tissue (log2 FC = +0.566, t-test p < 0.001).
This table shows molecular features associated with OSBPL11 in patient tissues and cancer cell lines. In patient samples, OSBPL11 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, OSBPL11 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and LARGE_INTESTINE.
