OSBPL11

Across TCGA patient cohorts, OSBPL11 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL11-associated genes across cancer lineages are HER3_pY1289, ATM, and Caspase-7-cleavedD198. Each is linked with OSBPL11 in more than 2 cancer types. Because this analysis shows association rather than direction, both OSBPL11-to-partner and partner-to-OSBPL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by OSBPL11-low versus OSBPL11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL11→partner) and Y-score (partner→OSBPL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.062	+1.894	.044	.030	3	3
UCEC	ATM →	-0.566	-3.906	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.490	+1.604	.021	.041	3	3
UCEC	Notch1 →	+0.186	+1.584	<.001	.019	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.387	-2.222	.016	.010	3	2
UCEC	AR →	-0.371	-1.925	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

HER3_pY1289 by OSBPL11 expression — UCEC

Explore this box plot interactively →