OSBPL11

Across TCGA pan-cancer cohorts, OSBPL11 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of OSBPL11’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OSBPL11 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types OSBPL11 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where OSBPL11 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OSBPL11 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.333	<.001	11	view →
LUAD	All	All	−0.103	<.001	8	view →
COAD	Male	All	−0.140	<.001	5	view →
CCRCC	Male	All	−0.083	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

OSBPL11–HNSC

Open the HNSC breakdown →