OSBPL11

Across TCGA patient cohorts, OSBPL11 mutation is significantly associated with the RNA expression of many other genes, with 3,055 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL11-associated genes across cancer lineages are TXN2P1, RN7SL134P, and LINC02559. Each is linked with OSBPL11 in more than 2 cancer types. Because this analysis shows association rather than direction, both OSBPL11-to-partner and partner-to-OSBPL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXN2P1 grouped by OSBPL11-low versus OSBPL11-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL11→partner) and Y-score (partner→OSBPL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TXN2P1 →	+0.295	+3.679	.001	.007	3	3
SKCM	RN7SL134P →	+0.150	+4.118	<.001	.004	3	3
CESC	LINC02559 →	+0.749	+4.020	<.001	.009	3	2
CESC	RN7SL26P →	+0.149	+4.027	<.001	<.001	3	2
CESC	MIR4510 →	+0.165	+4.020	<.001	.009	3	2
CESC	NF1P10 →	+0.097	+4.247	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,055 associations by consensus.

TXN2P1 by OSBPL11 expression — LUAD

Explore this box plot interactively →