OSBPL11

Across TCGA cell cohorts, OSBPL11 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OSBPL11-associated genes across cancer lineages are FAM205A, GSTA3, and IFNW1. Each is linked with OSBPL11 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBPL11-to-partner and partner-to-OSBPL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205A grouped by OSBPL11-low versus OSBPL11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL11→partner) and Y-score (partner→OSBPL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	1
OVARY	GSTA3 →	+0.104	+5.339	<.001	<.001	3	1
OVARY	IFNW1 →	+0.052	+4.029	<.001	.009	3	1
BLOOD_Leukemia	PRSS38 →	+0.205	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CTXN3 →	+0.012	+5.201	<.001	.006	3	1
BLOOD_Leukemia	MGAT4D →	+0.021	+4.922	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FAM205A by OSBPL11 expression — LARGE_INTESTINE

Explore this box plot interactively →