OSBPL11

Across TCGA pan-cancer cohorts, OSBPL11 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OSBPL11 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher OSBPL11 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated OSBPL11 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, GBM, and COAD are the cancer types where OSBPL11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.855	0.336	<.001	45	view →
GBM	DFS	Median	All	0.222	0.520	<.001	38	view →
COAD	DFS	Tertile	II,III,IV	0.875	1.000	.017	36	view →
CCRCC	DFS	Quartile	All	0.483	1.000	.019	11	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	3	view →
LUAD	OS	Tertile	All	1.000	0.934	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OSBPL11–LSCC (DFS)

Open the LSCC breakdown →