Q-omics provides the consensus-scored NUP205 profile across patient tissues and cancer cell-line models. NUP205 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, NUP205 is differentially expressed in 15, with the highest sampling consensus in HNSC. Additionally, NUP205 protein abundance shows 30,329 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight LIHC, HNSC, and LSCC as cancer lineages where NUP205 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NUP205 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NUP205 survival associations across molecular data types. NUP205 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (8) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NUP205 RNA expression–survival associations across cancer types. High NUP205 expression shows unfavorable associations in LIHC, ACC, MESO, LGG and KICH, but favorable associations in KIRC. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for NUP205 RNA expression.
This table summarizes NUP205 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 7. The strongest signals are observed in HNSC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for NUP205. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NUP205 shows higher tumor expression in HNSC, COAD, KIRP, LIHC, BLCA and LUAD. The HNSC box plot shows higher NUP205 RNA expression in tumor versus normal tissue (log2 FC = +1.142, t-test p < 0.001).
This table shows molecular features associated with NUP205 in patient tissues and cancer cell lines. In patient samples, NUP205 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, NUP205 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in BONE and BLOOD_Leukemia.
