NUP205

Across TCGA cell cohorts, NUP205 mutation is significantly associated with the RNA expression of many other genes, with 1,151 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUP205-associated genes across cancer lineages are CEP76, PIH1D1, and USP46. Each is linked with NUP205 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP205-to-partner and partner-to-NUP205 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP76 grouped by NUP205-low versus NUP205-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP205→partner) and Y-score (partner→NUP205) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CEP76 →	+0.553	+1.850	.004	.006	3	2
LARGE_INTESTINE	PIH1D1 →	+0.506	+2.584	<.001	.002	3	2
LARGE_INTESTINE	USP46 →	+0.607	+3.321	.001	.003	3	2
LARGE_INTESTINE	GPR63 →	+0.972	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	TAF12 →	+0.519	+3.129	<.001	<.001	3	2
LARGE_INTESTINE	NQO2 →	+1.062	+3.043	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,151 associations by consensus.

CEP76 by NUP205 expression — LARGE_INTESTINE

Explore this box plot interactively →