NUP205

Across TCGA cell cohorts, NUP205 mutation is significantly associated with the mutation status of many other genes, with 6,239 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUP205-associated genes across cancer lineages are SPEN, POLR3A, and CDK12. Each is linked with NUP205 in more than 5 cancer types. Because this analysis shows association rather than direction, both NUP205-to-partner and partner-to-NUP205 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPEN grouped by NUP205-low versus NUP205-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP205→partner) and Y-score (partner→NUP205) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPEN →	+1.963	+2.495	<.001	<.001	1	6
LUNG_NSCLC_LUAD	POLR3A →	+3.718	+3.718	.003	.003	1	5
LUNG_NSCLC_LUAD	CDK12 →	+4.303	+4.000	.001	.001	1	5
LUNG_NSCLC_LUAD	ITSN2 →	+5.303	+4.339	<.001	<.001	1	5
CNS	BCL9 →	+3.055	+3.786	.006	.006	1	5
OVARY	ANKRD31 →	+4.095	+2.754	.009	.009	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,239 associations by consensus.

SPEN by NUP205 expression — LARGE_INTESTINE

Explore this box plot interactively →