NUP205

Across TCGA pan-cancer cohorts, NUP205 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NUP205 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUP205 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUP205 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where NUP205 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.639	0.928	<.001	87	view →
PDAC	DFS	Tertile	All	0.286	0.548	.003	21	view →
UCEC	DFS	Median	All	0.838	0.969	.017	18	view →
HNSC	OS	Quartile	All	0.140	1.000	.017	15	view →
LUAD	DFS	Median	III,IV	0.716	0.332	.011	11	view →
LSCC	DFS	Quartile	II,III,IV	0.929	0.503	.013	6	view →
GBM	OS	Quartile	All	0.546	0.279	.012	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NUP205–CCRCC (DFS)

Open the CCRCC breakdown →