NUP205

Across TCGA patient cohorts, NUP205 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP205-associated genes across cancer lineages are FASN, Caspase-7-cleavedD198, and C-Raf. Each is linked with NUP205 in more than 2 cancer types. Because this analysis shows association rather than direction, both NUP205-to-partner and partner-to-NUP205 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by NUP205-low versus NUP205-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP205→partner) and Y-score (partner→NUP205) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.446	+2.115	.001	.017	3	3
COAD	Caspase-7-cleavedD198 →	+1.032	+2.601	<.001	.005	3	3
UCEC	C-Raf →	+0.101	+1.222	.013	.032	3	3
UCEC	DJ-1 →	+0.094	+1.054	.046	.029	3	3
BLCA	p62 Lck ligand →	+0.309	+2.459	.047	.020	3	2
BLCA	S6 →	+0.450	+2.459	.027	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

FASN by NUP205 expression — COAD

Explore this box plot interactively →